EdenteV2, Main, Exploration, bibRecord, 001C53

Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations

Identifieur interne : 001C53 ( Main/Exploration ); précédent : 001C52; suivant : 001C54

Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations

Auteurs : Gustavo Davi Rabelo [France, Brésil] ; José Narciso Rosa Assunção [Brésil] ; Pascale Chavassieux [France] ; Haroldo Arid Soares [Brésil] ; Fabio Abreu Alves [Brésil] ; Celso Augusto Lemos [Brésil]

Source :

Journal of Maxillofacial & Oral Surgery [ 0972-8279 ] ; 2014.

RBID : PMC:4511882

Abstract

Purpose

Bisphosphonate (BP) therapy in the treatment of bone diseases and malignancy may induce a major side effect known as bisphosphonate-related osteonecrosis of the jaws (BRONJ). A particular view of this condition is reported in this case series investigating eight patients. The aim of the study was to evaluate the BRONJ lesions concerning their aspects and progression. Also, identify if it is possible to predict the degree of severity in these cases.

Methods

Patients were evaluated by their condition and systemic health. The lesions were evaluated in clinical and radiographic aspects. The patients were followed-up for 2 years.

Results

The patients presented with specific peculiarities, and the BRONJ lesions varied in several characteristics. The BRONJ lesions ranged from simple to severe conditions, and the complicated cases presented with major pain, swelling, secondary infection and an extensive necrotic area, classified with high grade of severity.

Conclusions

The patients presented here confirm the existence of a relation between multiple features and BRONJ and to understand the whole process of aggravation, all systemic and local information have to be taken into account, together with all data related to the BP utilized. Regardless of the low incidence of this side effect in relation to osteoporosis treatment, in some cases, the BRONJ may become a severe condition and compromise the patient’s quality of life.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511882

DOI: 10.1007/s12663-014-0707-8
PubMed: 26225065
PubMed Central: 4511882

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>Bisphosphonate (BP) therapy in the treatment of bone diseases and malignancy may induce a major side effect known as bisphosphonate-related osteonecrosis of the jaws (BRONJ). A particular view of this condition is reported in this case series investigating eight patients. The aim of the study was to evaluate the BRONJ lesions concerning their aspects and progression. Also, identify if it is possible to predict the degree of severity in these cases.</p>
</sec>
<sec><title>Methods</title>
<p>Patients were evaluated by their condition and systemic health. The lesions were evaluated in clinical and radiographic aspects. The patients were followed-up for 2 years.</p>
</sec>
<sec><title>Results</title>
<p>The patients presented with specific peculiarities, and the BRONJ lesions varied in several characteristics. The BRONJ lesions ranged from simple to severe conditions, and the complicated cases presented with major pain, swelling, secondary infection and an extensive necrotic area, classified with high grade of severity.</p>
</sec>
<sec><title>Conclusions</title>
<p>The patients presented here confirm the existence of a relation between multiple features and BRONJ and to understand the whole process of aggravation, all systemic and local information have to be taken into account, together with all data related to the BP utilized. Regardless of the low incidence of this side effect in relation to osteoporosis treatment, in some cases, the BRONJ may become a severe condition and compromise the patient’s quality of life.</p>
</sec>
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Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations

Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations

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Abstract

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